Drug interactions of Tegretol
CYP3A inhibitors : Combining ketoconazole increases the Cmax and AUC of tegretol by 2.4-fold and 7.3-fold, respectively, and decreases the Cmax and AUC of the active metabolite by 89% and 56%, respectively; other strong inhibitors of CYP3A4 can have similar effects. Combination of this product with potent inhibitors of CYP3A (ketoconazole, itraconazole, voriconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, atazanavir, and telithromycin) should be avoided (see [Co…